What is an alternative to Ozempic?
Ozempic is a popular treatment for weight loss, but it is not the holy grail for everyone. Fortunately, there are several effective alternatives available with other active ingredients or dosage forms. In this blog, you will discover what medical treatments are available, what science says about their effectiveness, and how Goodweigh helps you make the right choice.
Why would you look for an alternative to Ozempic?
Not everyone responds the same way to semaglutide (the active ingredient in Ozempic). Sometimes factors such as medical contraindications, availability, unwanted side effects, or simply personal preference come into play. Especially if you prefer not to use injections, another medication may be better suited to your goals and lifestyle.
What other weight loss medications are similar to Ozempic?
There are several treatments that work in a similar way. Most belong to the GLP-1 group: medications that reduce your appetite and help you eat less. Below you can read what science says about these alternatives.
Wegovy
Wegovy contains the active ingredient semaglutide, just like Ozempic, but often in a higher dosage specifically for obesity. Leading research published in The New England Journal of Medicine shows that participants lost an average of 17% of their body weight in combination with lifestyle coaching (Wilding et al., 2021). In concrete terms, this means that someone weighing 100 kilograms lost an average of almost 17 kilograms, making it a very powerful alternative.
Mounjaro
Mounjaro (tirzepatide) is an innovative drug that activates two hormones simultaneously: GIP and GLP-1. This has a dual effect on both appetite and blood sugar. In large-scale clinical studies, participants lost an average of up to 22% of their body weight (Jastreboff et al., 2022). This makes tirzepatide statistically one of the most effective options for drug-induced weight loss at this time.
Saxenda
Saxenda (liraglutide) is an earlier generation GLP-1 medication that must be injected daily. Scientific research has shown that users achieved an average weight loss of about 10% after 56 weeks (Pi-Sunyer et al., 2015). Although its effect is slightly less powerful than that of the latest drugs, Saxenda has been on the market for years and its safety profile has been thoroughly documented.
Rybelsus
Rybelsus is unique because it contains semaglutide in tablet form. This makes it an interesting alternative for those who prefer not to inject. According to data from recent clinical studies (including O'Neil et al.), an average weight loss of 5-8% was observed at higher doses. Although the effect is generally less pronounced than with injections, it offers an accessible entry point for many.
What if you prefer not to use injections?
For those who find injections difficult, there are options such as Rybelsus, a pill containing oral semaglutide that is taken once a day. This can be a good alternative for people who do not want to inject.
Are there natural or non-medicinal alternatives?
Medication is a tool, not a substitute for a healthy foundation. Countless studies show that lifestyle interventions are essential for long-term success. Targeted changes in diet, calorie management, and exercise alone can lead to health benefits. When combined with medication, these pillars reinforce the effect and help maintain weight loss over the long term.
How does Goodweigh help you choose between the options?
At Goodweigh, you are not alone. Because every body reacts differently, a personalized approach is crucial.
- Medical Intake: You start with a comprehensive intake where a doctor assesses your health and medication history to choose the safest option.
- Lifestyle Coaching: You work with a coach on behavioral change, supported by webinars and articles on nutrition and mindset.
- Ongoing Monitoring: During the process, we make adjustments where necessary to ensure that the treatment remains safe, effective, and appropriate for your situation.
Discover which alternative is right for you
There are several effective options besides Ozempic, both injectable and oral variants. The best choice depends on your body, goals, and preferences. With medical guidance and a customized plan, you can make an informed choice that is right for you. Schedule an intake at Goodweigh and discover which treatment suits your situation.
References
- Zorginstituut Nederland. (2026, 18 februari). semaglutide. https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/s/semaglutide
- Zorginstituut Nederland. (2026, 18 februari). liraglutide. https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/l/liraglutide
- orginstituut Nederland. (2024, 29 maart). GVS-advies tirzepatide (Mounjaro). https://www.zorginstituutnederland.nl/publicaties/adviezen/2024/03/29/gvs-advies-tirzepatide-mounjaro-bij-diabetes-mellitus-type-2
- Bijwerkingencentrum Lareb. (2023, 17 maart). Risico's bij bloedsuikerverlagende geneesmiddelen voor afvallen. https://www.lareb.nl/news/risico-s-bij-bloedsuikerverlagende-geneesmiddelen-voor-afvallen/
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